In this study investigators will use magnesium sulphate in the nebulized form in children between 2 and 12 years of age as an acute reliever for acute severe asthma. Aim of this study is to determine that whether adding low (250mg), intermediate (500mg), and high doses (750mg) of magnesium sulphate in the 1st hour of treatment has any difference in the improvement of clinical condition of the patient and length of hospital stay. There will be total 108 patients having 2 groups. 1st group will receive only Ventolin while 2nd group will be given Ventolin and Magnesium sulphate.
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Change in Pediatric Respiratory Assessment Measure (PRAM) score from the baseline
Timeframe: 20, 40, 60, 120, 360, 720, 1080, 1440 minutes after commencement of treatment
Change from baseline Suprasternal indrawing
Timeframe: 20, 40, 60, 120, 360, 720, 1080, 1440 minutes after commencement of treatment
Change from baseline Scalene retractions
Timeframe: 20, 40, 60, 120, 360, 720, 1080, 1440 minutes after commencement of treatment
Change from baseline Wheezing
Timeframe: 20, 40, 60, 120, 360, 720, 1080, 1440 minutes after commencement of treatment
Change from baseline Air entry
Timeframe: 20, 40, 60, 120, 360, 720, 1080, 1440 minutes after commencement of treatment
Change from baseline Oxygen saturation on room air
Timeframe: 20, 40, 60, 120, 360, 720, 1080, 1440 minutes after commencement of treatment