CompletedPhase 1

Different Doses of Nebulized Magnesium Sulphate in Status Asthmaticus

Pakistan126 participantsStarted 2022-01-01

Plain-language summary

In this study investigators will use magnesium sulphate in the nebulized form in children between 2 and 12 years of age as an acute reliever for acute severe asthma. Aim of this study is to determine that whether adding low (250mg), intermediate (500mg), and high doses (750mg) of magnesium sulphate in the 1st hour of treatment has any difference in the improvement of clinical condition of the patient and length of hospital stay. There will be total 108 patients having 2 groups. 1st group will receive only Ventolin while 2nd group will be given Ventolin and Magnesium sulphate.

Who can participate

Age range

2 Years – 12 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. Children between 2 to 12 years of age.
. Children with the diagnosis of asthma having a pram score of more than 4.
. Children with reactive airways

Exclusion criteria

. Critically ill children who require intubation or mechanical ventilation.
. Having hypersensitivity or allergy to MgSO4.
. with history of chronic lung impairment.
. Whose parents are not giving informed consent for participation in research.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Change in Pediatric Respiratory Assessment Measure (PRAM) score from the baseline

Timeframe: 20, 40, 60, 120, 360, 720, 1080, 1440 minutes after commencement of treatment

Change from baseline Suprasternal indrawing

Timeframe: 20, 40, 60, 120, 360, 720, 1080, 1440 minutes after commencement of treatment

Change from baseline Scalene retractions

Timeframe: 20, 40, 60, 120, 360, 720, 1080, 1440 minutes after commencement of treatment

Change from baseline Wheezing

Timeframe: 20, 40, 60, 120, 360, 720, 1080, 1440 minutes after commencement of treatment

Change from baseline Air entry

Timeframe: 20, 40, 60, 120, 360, 720, 1080, 1440 minutes after commencement of treatment

Change from baseline Oxygen saturation on room air

Timeframe: 20, 40, 60, 120, 360, 720, 1080, 1440 minutes after commencement of treatment

Trial details

NCT IDNCT04929626

SponsorZiauddin University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-11-12

View on ClinicalTrials.gov More Status Asthmaticus trials

Plain-language summary

Who can participate

Age range

2 Years – 12 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. Children between 2 to 12 years of age.
. Children with the diagnosis of asthma having a pram score of more than 4.
. Children with reactive airways

Exclusion criteria

. Critically ill children who require intubation or mechanical ventilation.
. Having hypersensitivity or allergy to MgSO4.
. with history of chronic lung impairment.
. Whose parents are not giving informed consent for participation in research.

What they're measuring

Change in Pediatric Respiratory Assessment Measure (PRAM) score from the baseline

Timeframe: 20, 40, 60, 120, 360, 720, 1080, 1440 minutes after commencement of treatment

Change from baseline Suprasternal indrawing

Timeframe: 20, 40, 60, 120, 360, 720, 1080, 1440 minutes after commencement of treatment

Change from baseline Scalene retractions

Timeframe: 20, 40, 60, 120, 360, 720, 1080, 1440 minutes after commencement of treatment

Change from baseline Wheezing

Timeframe: 20, 40, 60, 120, 360, 720, 1080, 1440 minutes after commencement of treatment

Change from baseline Air entry

Timeframe: 20, 40, 60, 120, 360, 720, 1080, 1440 minutes after commencement of treatment

Change from baseline Oxygen saturation on room air

Timeframe: 20, 40, 60, 120, 360, 720, 1080, 1440 minutes after commencement of treatment