Osteoarthritis is the most common musculoskeletal disease and is characterized by cartilage destruction, osteophyte formation, subchondral bone sclerosis and cysts. Modern treatment strategies, as well as preventive measures, include early detection and knowledge of the early course of the disease. This includes how stress patterns, physical activity, impaired function and metabolic changes and other comorbidities affect development and possible associations with osteoarthritis. The overall objective was to study the early development of osteoarthritis of the knee and its association with hand- and general osteoarthritis, metabolic diseases, biomarkers, long-term pain, physical function and stress patterns
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BMI (kg/m2)
Timeframe: At baseline
BMI (kg/m2)
Timeframe: At 2 years follow-up
BMI (kg/m2)
Timeframe: At 5 years follow-up
Abdominal circumference (cm)
Timeframe: At baseline
Abdominal circumference (cm)
Timeframe: At 2 years follow-up
Abdominal circumference (cm)
Timeframe: At 5 years follow-up
Body composition
Timeframe: At baseline
Body composition
Timeframe: At 2 years follow-up
Body composition
Timeframe: At 5 years follow-up
Glucos
Timeframe: At Baseline
Glucos
Timeframe: At 1 year follow-up
Glucos
Timeframe: At 2 years follow-up
Glucos
Timeframe: At 3 years follow-up
Glucos
Timeframe: At 4 years follow-up
Glucos
Timeframe: At 5 years follow-up
HbA1c
Timeframe: At baseline
HbA1c
Timeframe: At 1 year follow-up
HbA1c
Timeframe: At 2 years follow-up
HbA1c
Timeframe: At 3 years follow-up
HbA1c
Timeframe: At 4 years follow-up
HbA1c
Timeframe: At 5 years follow-up
Total-cholesterol
Timeframe: At baseline
Total-cholesterol
Timeframe: At 1 year follow-up
Total-cholesterol
Timeframe: At 2 years follow-up
Total-cholesterol
Timeframe: At 3 years follow-up
Total-cholesterol
Timeframe: At 4 years follow-up
Total-cholesterol
Timeframe: At 5 years follow-up
Triglycerides
Timeframe: At baseline
Triglycerides
Timeframe: At 1 year follow-up
Triglycerides
Timeframe: At 2 years follow-up
Triglycerides
Timeframe: At 3 years follow-up
Triglycerides
Timeframe: At 4 years follow-up
Triglycerides
Timeframe: At 5 years follow-up
LDL-cholesterol
Timeframe: At baseline
LDL-cholesterol
Timeframe: At 1 year follow-up
LDL-cholesterol
Timeframe: At 2 years follow-up
LDL-cholesterol
Timeframe: At 3 years follow-up
LDL-cholesterol
Timeframe: At 4 years follow-up
LDL-cholesterol
Timeframe: At 5 years follow-up
HDL-cholesterol
Timeframe: At baseline
HDL-cholesterol
Timeframe: At 1 year follow-up
HDL-cholesterol
Timeframe: At 2 years follow-up
HDL-cholesterol
Timeframe: At 3 years follow-up
HDL-cholesterol
Timeframe: At 4 years follow-up
HDL-cholesterol
Timeframe: At 5 years follow-up
Sensitive C-Reactive Protein (CRP)
Timeframe: At baseline
Sensitive C-Reactive Protein (CRP)
Timeframe: At 1 year follow-up
Sensitive C-Reactive Protein (CRP)
Timeframe: At 2 years follow-up
Sensitive C-Reactive Protein (CRP)
Timeframe: At 3 years follow-up
Sensitive C-Reactive Protein (CRP)
Timeframe: At 4 years follow-up
Sensitive C-Reactive Protein (CRP)
Timeframe: At 5 years follow-up
Interleukin-1 (IL-1)
Timeframe: At baseline
Interleukin-1 (IL-1)
Timeframe: At 1 year follow-up
Interleukin-1 (IL-1)
Timeframe: At 2 years follow-up
Interleukin-1 (IL-1)
Timeframe: At 3 years follow-up
Interleukin-1 (IL-1)
Timeframe: At 4 years follow-up
Interleukin-1 (IL-1)
Timeframe: At 5 years follow-up
Interleukin-6 (IL-6)
Timeframe: At baseline
Interleukin-6 (IL-6)
Timeframe: At 1 year follow-up
Interleukin-6 (IL-6)
Timeframe: At 2 years follow-up
Interleukin-6 (IL-6)
Timeframe: At 3 years follow-up
Interleukin-6 (IL-6)
Timeframe: At 4 years follow-up
Interleukin-6 (IL-6)
Timeframe: At 5 years follow-up
Tumor Necrosis Factor-alfa (TNF-alfa)
Timeframe: At baseline
Tumor Necrosis Factor-alfa (TNF-alfa)
Timeframe: At 1 year follow-up
Tumor Necrosis Factor-alfa (TNF-alfa)
Timeframe: At 2 years follow-up
Tumor Necrosis Factor-alfa (TNF-alfa)
Timeframe: At 3 years folllow-up
Tumor Necrosis Factor-alfa (TNF-alfa)
Timeframe: At 4 years follow-up
Tumor Necrosis Factor-alfa (TNF-alfa)
Timeframe: At 5 years follow-up
Leptin
Timeframe: At baseline
Leptin
Timeframe: At 1 year follow-up
Leptin
Timeframe: At 2 years follow-up
Leptin
Timeframe: At 3 years follow-up
Leptin
Timeframe: At 4 years follow-up
Leptin
Timeframe: At 5 years follow-up
Galectin-1
Timeframe: At baseline
Galectin-1
Timeframe: At 1 year follow-up
Galectin-1
Timeframe: At 2 years follow-up
Galectin-1
Timeframe: At 3 years follow-up
Galectin-1
Timeframe: At 4 years follow-up
Galectin-1
Timeframe: At 5 years follow-up
One-leg rise
Timeframe: At baseline
One-leg rise
Timeframe: At 2 years follow-up
One-leg rise
Timeframe: At 5 years follow-up
30s-chair stand test
Timeframe: At baseline
30s-chair stand test
Timeframe: At 2 years follow-up
30s-chair stand test
Timeframe: At 5 years follow-up
Maximal voluntary isometric contraction of Quadriceps
Timeframe: At baseline
Maximal voluntary isometric contraction of Quadriceps
Timeframe: At 2 years follow-up
Maximal voluntary isometric contraction of Quadriceps
Timeframe: At 5 years follow-up
Hand strenght
Timeframe: At baseline
Hand strenght
Timeframe: At 2 years follow-up
Hand strenght
Timeframe: At 5 years follow-up
Fitness
Timeframe: At 2 years follow-up
Fitness
Timeframe: At 5 years follow-up
Pain thresholds
Timeframe: At baseline
Pain thresholds
Timeframe: At 2 years follow-up
Pain thresholds
Timeframe: At 5 years follow-up
Knee injury and osteoarthritis outcome score (KOOS)
Timeframe: At baseline
Knee injury and osteoarthritis outcome score (KOOS)
Timeframe: At 1 year follow-up
Knee injury and osteoarthritis outcome score (KOOS)
Timeframe: At 2 years follow-up
Knee injury and osteoarthritis outcome score (KOOS)
Timeframe: At 3 years follow-up
Knee injury and osteoarthritis outcome score (KOOS)
Timeframe: At 4 years follow-up
Knee injury and osteoarthritis outcome score (KOOS)
Timeframe: At 5 years follow-up
Pain mannequin
Timeframe: At baseline
Pain mannequin
Timeframe: At 1 year follow-up
Pain mannequin
Timeframe: At 2 years follow-up
Pain mannequin
Timeframe: At 3 years follow-up
Pain mannequin
Timeframe: At 4 years follow-up
Pain mannequin
Timeframe: At 5 years follow-up
Pain intensity
Timeframe: At baseline
Pain intensity
Timeframe: At 1 year follow-up
Pain intensity
Timeframe: At 2 years follow-up
Pain intensity
Timeframe: At 3 years follow-up
Pain intensity
Timeframe: At 4 years follow-up
Patient intensity
Timeframe: At 5 years follow-up
Radiographic assessment of the knees
Timeframe: At baseline
Radiographic assessment of the knees
Timeframe: At 1 year follow-up
Radiographic assessment of the knees
Timeframe: At 2 years follow-up
Radiographic assessment of the knees
Timeframe: At 3 years follow-up
Radiographic assessment of the knees
Timeframe: At 4 years follow-up
Radiographic assessment of the knees
Timeframe: At 5 years follow-up
Radiographic assessment of the hands
Timeframe: At 2 years follow-up
Radiographic assessment of the hands
Timeframe: At 5 years follow-up
Mechanical load
Timeframe: At inclusion
Mechanical load
Timeframe: At 2 years follow-up
Mechanical load
Timeframe: At 5 years follow-up