A Study of a Single Dose of Inclacumab to Reduce Re-admission in Participants With Sickle Cell Disease and Recurrent Vaso-occlusive Crises

Inclusion criteria

• ✓. Participant has an index VOC. The index VOC is any VOC that required admission to a healthcare facility and treatment with parenteral pain medication. An admission for the index VOC includes:
• ✓. A hospital admission, or
• ✓. An admission to an emergency room, observation unit, or infusion center for ≥ 12 hours, or
• ✓. 2 visits to an emergency room, observation unit, or infusion center over a 72-hour period
• ✓. Participant has a confirmed diagnosis of SCD (any genotype). Documentation of SCD genotype is required and may be based on documented history of laboratory testing or confirmed by laboratory testing at Baseline.
• ✓. Participant is male or female, ≥ 12 years of age at the time of informed consent.
• ✓. Participant has experienced between 2 and 10 VOCs within the 12 months prior to Screening as determined by documented medical history. The index VOC is not to be considered as one of the 2 to 10 events. A prior VOC is defined as an acute episode of pain that:
• ✓. Has no medically determined cause other than a vaso-occlusive event, and

Exclusion criteria