Auryxia (Ferric Citrate) Therapy for In-Center and Home Dialysis Participants (NCT04922645) | Clinical Trial Compass
CompletedPhase 4
Auryxia (Ferric Citrate) Therapy for In-Center and Home Dialysis Participants
United States214 participantsStarted 2021-06-29
Plain-language summary
This study is being conducted to demonstrate the effect of Auryxia, when used as the primary phosphate lowering therapy, on the overall cumulative use of erythropoiesis-stimulating agent and intravenous iron as well as on the laboratory parameters indicative of phosphate and anemia management.
Who can participate
Age range18 Years
SexALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
ā. Adult participants greater or equal to 18 years old.
ā. Diagnosis of end-stage kidney disease and receiving maintenance dialysis (in-center, home hemodialysis or peritoneal dialysis) for greater or equal to 12 weeks prior to randomization.
ā. Most recent transferrin saturation less than or equal to 50 percent
ā. Most recent serum phosphate is greater or equal to 3.0 milligrams per deciliter
ā. Receiving treatment for greater or equal to 8 weeks prior to screening with non-Auryxia phosphate lowering therapy. No requirement for stable dosing within this time frame.
ā. Receiving treatment for greater or equal to 8 weeks prior to screening with erythropoiesis-stimulating agent (any dose, any type). No requirement for stable dosing within this time frame.
ā. Understands the procedures and requirements of the study and provides written informed consent and authorization for protected health information disclosure.
Exclusion criteria
ā. A known allergy or intolerance to Auryxia or any of its constituents.
ā. Hypersensitivity reaction to previous oral iron therapy.
ā. History of hemochromatosis or other iron overload syndrome.
ā. Active malignancy requiring current treatment except for non-melanoma skin cancer regardless of treatment.
What they're measuring
1
Difference in mean dose of erythropoiesis-stimulating agent (standardized Units per month) between Auryxia and standard of care treatment groups
Timeframe: Baseline period (Month -3 to Day 1) to months 4to 6 (efficacy evaluation period)
2
Difference in mean dose of intravenous iron (milligram per month) between Auryxia and standard of care treatment groups.
Timeframe: Baseline period (Month -3 to Day 1) to months 4 to6 (efficacy evaluation period)
ā. Active drug or alcohol dependence or abuse (excluding tobacco use or medicinal or recreational marijuana) within the 12 months prior to Screening or evidence of such abuse (in the opinion of the Investigator).
ā. Limited life expectancy (less than 6 months), (in the opinion of the Investigator).
ā. Scheduled organ transplant and participants on the kidney transplant wait-list who are expected to receive a transplant within 6 months of screening. Being active on transplant list is not an exclusion. Previous kidney transplant is not an exclusion.
ā. Unable to comply with study requirements or in the opinion of the Investigator not clinically stable to participate in the study.