Hypertonic Saline for MAC

Inclusion Criteria: * At least 2 positive MAC sputum cultures in the last 12 months with at least one AFB positive sputum obtained within 12 weeks prior to randomization * Meet American Thoracic Society (ATS)/ Infectious Disease Society of America (IDSA) 2007 pulmonary clinical disease criteria\[1\] * Age 18 and older * Diagnosis of Bronchiectasis and/or bronchiectatic findings evident on chest CT report * Ability to provide informed consent Exclusion Criteria: * Any patient who is unwilling or unable to provide consent or to comply with this protocol * Cavitary NTM disease * Patients who are currently taking or within the prior 6 months received any of the following: bedaquiline, or any component of ATS/IDSA multi-drug recommended therapy (macrolide, ethambutol, rifampin) for MAC treatment * Diagnosis of HIV * Diagnosis of Cystic fibrosis * Active pulmonary tuberculosis, fungal, or nocardial disease requiring treatment at screening * Current use of chronic systemic corticosteroids at doses of 15 mg/day for more than 3 months * Prior lung or other solid organ transplant