This clinical study will evaluate the safety, tolerability, and reactogenicity of 2 dose levels of messenger RNA (mRNA)-1893 Zika vaccine in comparison to a placebo control in healthy participants who are flavivirus-seronegative and in participants who are flavivirus-seropositive.
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Number of Participants With Solicited Local and Systemic Reactogenicity Adverse Reactions (ARs)
Timeframe: Up to 7 days post-vaccination
Number of Participants With Unsolicited Adverse Events (AEs)
Timeframe: Up to 28 days post-vaccination
Number of Participants With Serious Adverse Events (SAEs), AEs of Special Interest (AESIs)
Timeframe: Day 1 through Day 196 for Main Study and Day 197 through Day 700 for Extension Period
Number of Participants With Medically Attended AEs (MAAEs)
Timeframe: Day 1 through Day 196 for Main Study and Day 197 through Day 700 for Extension Period
Geometric Mean Titer (GMT) of Zika Virus (ZIKV)-Specific Neutralizing Antibodies (nAbs) at Day 57, as Measured by 50% Plaque Reduction Neutralization Test (PRNT50)
Timeframe: Day 57
GMT of ZIKV-specific nAbs at Day 57, as Measured by 80% Plaque Reduction Neutralization Test (PRNT80)
Timeframe: Day 57
Percentage of Participants With Seroconversion at Day 57, as Measured by PRNT50
Timeframe: Day 57
Percentage of Participants With Seroconversion at Day 57, as Measured by PRNT80
Timeframe: Day 57