CompletedNot Applicable

Impact of Obesity on Post-operative Cognitive Dysfunction: Role of Adipose Tissue

France115 participantsStarted 2021-09-21

Plain-language summary

This research aims at describing the relationship between white adipose tissue inflammation and post-operative cognitive dysfunctions.The possible link between inflammatory cytokines secretions of the white adipose tissue of a surgical wound and the arising of patient's cognitive dysfunction in the post-operative course will be investigated. The hypothesis is that obese patient's inflammation of the white adipose tissue leads to cognitive dysfunction.

Who can participate

Age range60 Years – 99 Years

SexALL

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Inclusion Criteria: * patient about to receive a hip arthroplasty under general anesthesia, elective cardiac surgery with cardiopulmonary bypass, * patient with a MMSE score \> or = 20(/30), * patient able to give informed consent Exclusion Criteria: * emergency surgery, or surgery in a septic context, * patient with a known dementia or altered MMSE score (under 20)

What they're measuring

Arising of POCD measured by a composite criterion

Timeframe: day 5 after surgery

Trial details

NCT IDNCT04907565

SponsorUniversity Hospital, Toulouse

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2024-09-30

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