Induction of Labor by Oral Misoprostol Solution (NCT04891679) | Clinical Trial Compass
CompletedNot Applicable
Induction of Labor by Oral Misoprostol Solution
India264 participantsStarted 2017-12-01
Plain-language summary
AIM: To evaluate effectiveness and safety of titrated oral misoprostol solution (OMS) in comparison with static-dose oral misoprostol solution for induction of labor at term.
Women with singleton live pregnancy at term without any complications who were admitted in labor room for induction of labor were enrolled.
Study involves allocation of selected women in two groups randomly and use of either titrated or static oral misoprostol dose regimen to induce labor. Possible benefits included rapid induction of labor with oral drug regimen which is easier to comply as compared to vaginal regimens. Women were at risk of all the complications associated with induction of labor like labor abnormalities, risk of cesarean section, non reassuring fetal status.
Who can participate
Age range18 Years – 40 Years
SexFEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
✓. Singleton live pregnancy;
✓. ≥37 weeks gestation;
✓. Cephalic presentation;
✓. Reassuring fetal heart rate;
✓. Modified Bishop'score
Exclusion criteria
✕. Hypersensitivity to misoprostol;
✕. Uterine scar due to previous cesarean section or other uterine surgery;
✕. Grand multipara;
✕. Multiple gestations;
✕. High risk pregnanacies • preeeclampsia with severe features • significant maternal cardiac,renal, liver disease
✕. Any contraindication to induction and vaginal delivery e.g. cephalopelvic disproportion, malpresentation, fetal compromise and ante partum hemorrhage
What they're measuring
1
Interval between induction and delivery
Timeframe: From first dose of oral misoprostol solution (titrated/static) to childbirth; upto 5 days
Trial details
NCT IDNCT04891679
SponsorChristian Medical College and Hospital, Ludhiana, India