Study to assess the effects of weekly subcutaneous administration of the GLP1-RA semaglutide 2.4mg on kidney function parameters in obese/overweight individuals at high risk of CKD progression.
Who can participate
Age range18 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age ≥ 18 years
* Body Mass index ≥ 27 kg/m2
* Albuminuria ≥ 30 mg/g and ≤ 3500 mg/g
* eGFR ≥ 25 ml/min/1.73m2
* Stable renal function prior to entry into the study defined as no more than 30% eGFR change in 3 months prior to enrolment
* Signed Informed Consent
Exclusion Criteria:
* Diagnosis with type 1 or type 2 Diabetes
* Hba1c ≥ 6.5% at screening
* Cardiovascular disease event in 3 months prior to enrollment
* Treatment with GLP-1 RA \< 4 weeks prior to screening
* Uncontrolled thyroid disease TSH\>6.0 mIU/L or \<0.4 mIU/L at screening
* Acute pancreatitis \< 180 days prior to screening
* History or presence of chronic pancreatitis
* Females of child-bearing potential who are pregnant, breast-feeding or have intention of becoming pregnant or are not using adequate contraceptive measures
What they're measuring
1
Change from baseline to week 24 in urinary albumin:creatinine ratio (UACR)