pAF for the Treatment of Osteoarthritis

Inclusion Criteria: * Patients who are between the ages of 18-70 years * A confirmed diagnosis of knee osteoarthritis based on clinical and radiographic findings consistent with Kellgren-Lawrence Stage 2-3 disease * Patients who have failed conservative treatment (e.g. steroid, activity modification, therapy, etc.) within 3 months * Unilateral or bilateral chronic knee joint pain \>4 months * Patients who are able to ambulate (i.e. not wheelchair bound) * Patient reported a typical pain of at least 4 out of 10 during the past week using VAS numeric pain scale (0-10) * Patients who are of childbearing potential must agree to use adequate contraception for 90 days after study drug injection Exclusion Criteria: * Subjects who have had a previous injection (i.e. steroid, platelet rich plasma, or other) within the last 3 months * A focal chondral defect, defined by x-ray evaluation * BMI \>40 as defined by NIH Clinical Guidelines Body Mass Index * Concurrent participation in another investigational trial involving systemic administration of agents (within the previous 30 days) or plans to participate in any other allogeneic stem cell therapy trial during the 12 month follow-up period * Clinical suspicion of infection at injection site * Any surgeries within 4 weeks, other than diagnostic surgery * Insulin or self-reported non-insulin dependent diabetic evident of HgA1c ≥8% among known diabetics * Unable to consent to an English Language Consent Form * Frank mechanical issues (i…