Bacille Calmette-Guerin (BCG) Vaccine for Immune Protection Against Infections

Inclusion Criteria (CF and non-CF bronchiectasis): * Confirmed diagnosis of either CF or non-CF bronchiectasis * Forced expiratory volume over one second (FEV1) \> 40% * Willingness to participate in the study after all aspects of the protocol have been explained and written informed consent obtained. * Available for the study duration, including all planned follow-up visits Inclusion Criteria (Healthy Volunteers): * Negative HIV enzyme-linked immunosorbent assay (ELISA) and confirmatory test at screening. * Willingness to participate in the study after all aspects of the protocol have been explained and written informed obtained. * Available for the study duration, including all planned follow-up visits Exclusion Criteria (All arms): * Current or prior history of active or latent tuberculosis (TB) (per report, not formally tested) or NTM infection * Prior BCG vaccination * Previous vaccine in the past 4 weeks * History of severe anaphylaxis to any vaccine or vaccine components * History of organ/bone marrow transplantation or other immunosuppressing condition, including HIV * Immunosuppressing drugs (including oral corticosteroids equivalent to \>10mg of prednisone for 5 days) in the 30 days prior to study enrollment * Cirrhosis or portal hypertension * Pregnant or breastfeeding * Receipt of another investigational product in the last 28 days or planned receipt during this study * Has any other condition that, in the opinion of the principal investigator, would preclude…