A Single and Multiple Ascending-dose Trial of LEO 153339 in Healthy Adults

Main Inclusion Criteria: * Healthy adult males and females. * Age between 18 and 65 years (both inclusive) at screening. * A body mass index (BMI) between 18.0 and 32.0 kg/m² (both inclusive). * In good health at screening and/or check-in (Day -2 and Day -1) as judged by the investigator based on medical history, physical examination, vital signs, 12 lead electrocardiogram (ECG), and clinical laboratory evaluations. Main Exclusion Criteria: * Male participants sexually active with a woman of childbearing potential who are not willing to use a barrier method of contraception (e.g. condom) from the time of first dose of investigational medicinal product (IMP) until 3 months after the last dose, in conjunction with this female partner using a highly effective form of contraception. For vasectomised male participants, male participants with a female partner with bilateral tubal occlusion or ligation, and heterosexually abstinent male participants (when this is in line with the preferred and usual life style of the participant and not just being without a current partner), no additional contraception is required. * Female participants who are pregnant, lactating, or of childbearing potential. * Any surgical or medical condition or cholecystectomy which might significantly alter the absorption, distribution, metabolism, or excretion of any drug. * Positive polymerase chain reaction (PCR) test for coronavirus disease 2019 (COVID-19) at Day -2 or Day -1 or within 8 weeks prior to …