Researchers are looking for a better way to treat people who have worsening of chronic heart failure, a long-term condition where the heart does not pump blood as well as it should, as well as to treat patients who have diabetic nephropathy, a long-term, progressive decrease in the kidneys' ability to work properly in patients with diabetes mellitus. In this study researchers wanted to learn more about a new substance called finerenone (BAY94-8862). Finerenone is a substance that blocks the activation of a protein in the body called mineralocorticoid receptor (MR). An increased activation of MR is involved in the development of hypertension, organ damage and worsening of heart failure. The researchers studied how finerenone moves into, through and out of the body. The researchers also looked at how safe finerenone is and how it affects the body. The main purpose of this study was to help researchers develop recommendations for the amount of the substance (the dosing) to be given to patients with reduced liver function.
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Area under the concentration versus time curve from zero to infinity (AUC) of finerenone in plasma
Timeframe: 0 hour pre-dose to 96 hour post-dose
Area under the concentration versus time curve from zero to infinity of unbound finerenone (AUCu) in plasma
Timeframe: 0 hour pre-dose to 96 hour post-dose
Maximum observed drug concentration (Cmax) of finerenone in plasma
Timeframe: 0 hour pre-dose to 96 hour post-dose
Maximum observed drug concentration of unbound finerenone (Cmax,u) in plasma
Timeframe: 0 hour pre-dose to 96 hour post-dose