Low-Dose Dexmedetomidine for Delirium Prevention in Mechanically Ventilated Septic Patients (NCT04876937) | Clinical Trial Compass
TerminatedNot Applicable
Low-Dose Dexmedetomidine for Delirium Prevention in Mechanically Ventilated Septic Patients
Stopped: The trial was stopped prematurely because of slow recruitment.
China42 participantsStarted 2021-05-28
Plain-language summary
Delirium is common in septic patients, especially those receiving mechanical ventilation in the intensive care unit (ICU). Dexmedetomidine is a highly selective α2 adrenoreceptor agonist with anxiolytic, sedative, analgesic, and anti-inflammatory effects. Use of dexmedetomidine in mechanically ventilated ICU patients is associated with less delirium and improved outcomes. However, dexmedetomidine infusion produces dose-dependent bradycardia and hypotension; these limited the use of dexmedetomidine in ICU patients. This study is designed to test the hypothesis that low-dose dexmedetomidine infusion can also reduce delirium in mechanically ventilated ICU patients with sepsis.
Who can participate
Age range18 Years
SexALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
✓. Aged 18 years or older;
✓. Admitted to the ICU;
✓. With expected mechanical ventilation duration ≥12 hours;
✓. Meet the diagnostic criteria of sepsis (sepsis 3.0; patient with infection and a sequential organ failure assessment score ≥2).
Exclusion criteria
✕. Refuse to participate in;
✕. Pregnancy;
✕. History of schizophrenia, epilepsy, parkinsonism, or myasthenia gravis;
✕. Inability to communicate (coma, profound dementia, or language barrier);
✕. Brain injury or neurosurgery;
✕. Left ventricular ejection fraction (LVEF) less than 30%, sick sinus syndrome, severe sinus bradycardia (\<50 beats per min \[bpm\]), or second degree or greater atrioventricular block without pacemaker;
What they're measuring
1
Incidence of delirium within the first 7 days after enrollment