Image-guided Proton Therapy for the Treatment of Locally Advanced Unresectable Head and Neck Cancer

Inclusion Criteria: * Biopsy proven diagnosis of squamous cell carcinoma of head and neck cancer originating in the oropharynx, hypopharynx, larynx, oral cavity (base of tongue) or nasopharynx. Clinical evidence should be documented, and may consist of imaging, endoscopic evaluation, palpation, and should be sufficient to estimate the image tumor characteristic of the primary tumor * Negative for HPV by p16 immunohistochemistry (IHC) or in situ hybridization (ISH) * Inoperable locally advances disease, i.e. stage \>= III and T stage \>= 2 * The primary radiotherapy, either in combination with chemotherapy or not, with curative intent * No head and neck surgery of the primary tumor or lymph nodes except for incisional or excisional biopsies * Eastern Cooperative Oncology Group (ECOG) = 0, 1, or 2 * For females of child-bearing age, a negative pregnancy test Exclusion Criteria: * Patients who have undergone definitive resection of their primary or nodal disease as well as any chemotherapy or radiation therapy for their head and neck squamous cell carcinoma (HNSCC) * Patient that refuse or are unable to stop smoking and/or consuming alcohol during and after radiotherapy. In addition, patients that refuse or fail tobacco and alcohol blood test * Patients that have no detectable no tumor in both the primary site and lymph nodes at week 4 in treatment, because there will not be a volume to boost * Patients unable or unwilling to give written, informed consent or to undergo magne…