Stopped: study was never fully reopened with the intuitional review board
Our overarching aim is to define the pathophysiology, epidemiology, and natural history of HO by following patients from date of injury until full wound healing has occurred and the window for HO has passed. Specific aims Aim 1: To classify the acute and chronic physiologic profiles of fracture patients and how they relate to the development of HO. Here the investigators will look at the systemic derangements to patients' coagulation, fibrinolytic, and inflammatory profiles. Aim 2: Identify the true incidence and time course of HO development after traumatic fracture. To accomplish this the investigators will look at patients who have sustained hip fracture, midshaft/distal femur fracture, humerus fracture, proximal radius fracture, and elbow dislocation/fractures and track follow-up images up to one year after injury looking for HO. Aim 3: Define the histologic characteristics of HO development. To accomplish this aim the investigators will perform a histologic analysis on a sample of injured muscle surrounding the fracture area. Aim 4: To determine what comorbid, iatrogenic, or environmental influences are associated with the formation of HO. To achieve this aim the investigators will evaluate data including injury type, surgery type, operative duration, surgical approach, contamination (open vs closed injury), complications (malunion, nonunion, infection, hardware failure, removal of hardware), hardware type, comorbidities (smoking, cardiac history, diabetes), and medications.
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Change of coagulation from baseline during hospitalization as measured by platelet count
Timeframe: Change of platelet count from baseline and during hospitalization (approximately 1-28 days)
Change of coagulation from baseline during hospitalization as measured by thrombin-antithrombin (TAT) complexes
Timeframe: Change of thrombin-antithrombin (TAT) from baseline and during hospitalization (approximately 1-28 days)
Change of fibrinolysis from baseline during hospitalization as measured by plasmin-antiplasmin complex (PAP)
Timeframe: Change of plasmin-antiplasmin complex (PAP) from baseline and during hospitalization (approximately 1-28 days)
Change of fibrinolysis from baseline during hospitalization as measured by D-dimer
Timeframe: Change of D-dimer from baseline and during hospitalization (approximately 1-28 days)
Change of inflammation from baseline during hospitalization as measured by C-reactive protein (CRP)
Timeframe: Change of C-reactive protein (CRP) from baseline and during hospitalization (approximately 1-28 days)
Change of inflammation from baseline during hospitalization as measured by IL-6
Timeframe: Change of IL-6 from baseline and during hospitalization (approximately 1-28 days)