This study is a Phase 1, open-label, non-randomized, 2-period, fixed-sequence, single-dose study of PF-06865571 in healthy male participants to characterize the ADME properties of \[14C\]PF-06865571 following oral administration; and to evaluate the absolute oral bioavailability (F) and fraction absorbed (Fa) of PF-06865571 following oral administration of unlabeled PF-06865571 and IV administration of \[14C\]PF-06865571.
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Total Recovery of Radioactivity in Urine as Percentage of Total Radioactive Dose of PF-06865571 Administered
Timeframe: Period 1: Day -1 to maximum Day 21; Period 2: Day 1 to maximum Day 3
Total Recovery of Radioactivity in Feces as Percentage of Total Radioactive Dose of PF-06865571 Administered
Timeframe: Period 1: Day -1 to maximum Day 21; Period 2: Day 1 to maximum Day 3
Total Recovery of Radioactivity in Total Excreta (Urine + Feces) as Percentage of Total Radioactive Dose of PF-06865571 Administered
Timeframe: Period 1: Day -1 to maximum Day 21; Period 2: Day 1 to maximum Day 3
Relative Abundance (Mean Value) of Radiolabeled PF-06865571 in Plasma in Period 1
Timeframe: Period 1: 0, 0.5, 1, 2, 3, 4, 6, 9, 12, 16, 24, 36, 48, 72, 96 and 120 hours post-dose (Day 1 to Day 6)
Relative Abundance (Mean Value) of Metabolites of Radiolabeled PF-06865571 in Plasma in Period 1
Timeframe: Period 1: 0, 0.5, 3, 6, 12, 24, 36, 48, 72, 96 and 120 hours post-dose (Day 1 to Day 6)
Relative Abundance (Mean Value) of Radiolabeled PF-06865571 in Urine in Period 1
Timeframe: Period 1: Day -1 to maximum Day 21
Relative Abundance (Mean Value) of Metabolites of Radiolabeled PF-06865571 in Urine in Period 1
Timeframe: Period 1: Day -1 to maximum Day 21
Relative Abundance (Mean Value) of Radiolabeled PF-06865571 in Feces in Period 1
Timeframe: Period 1: Day -1 to maximum Day 21
Relative Abundance (Mean Value) of Metabolites of Radiolabeled PF-06865571 in Feces in Period 1
Timeframe: Period 1: Day -1 to maximum Day 21