UnknownNot Applicable

DNA Adductomics for Colorectal Cancer Investigation

Denmark60 participantsStarted 2021-02-15

Plain-language summary

This project seeks to identify DNA-adducts in colon tissue from different groups of patients with CRC scheduled for complete or partial colon resections. Other patients scheduled for resection of the colon serve as controls. In addition, surrogate samples such as white blood cells are investigated for the presense of adducts while blood plasma and urine are investigated for the presense of DNA-repair products.

Who can participate

Age range18 Years

SexALL

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Inclusion Criteria: * Patients with either FAP, Lynch syndrome, other HNPCC, sporadic colorectal cancer, ulcerative colitis or other conditions who are scheduled for whole or partial resection of their colon Exclusion Criteria: * Any condition that makes the investigator or hospital personnel doubt that voluntary participation isfeasible. * Patients who are not able to understand and sign the informed consent form for any reason, including lack of a sufficient period of time to consider their participation. * Patients who are below 18 years of age. * Patients who donated blood to a blood bank within 3 months prior to their operation.

What they're measuring

DNA adductome in CRC and other diseases

Timeframe: During surgery

Correlation of DNA adduct and DNA repair products

Timeframe: Baseline (Before surgery)

Trial details

NCT IDNCT04865601

SponsorUniversity of Copenhagen

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2024-12-31

Contact for this trial

Lars Ove Drasted, professor

+4535332694 ldra@nexs.ku.dk

View on ClinicalTrials.gov More Colorectal Cancer trials