Evaluate the Efficacy and Safety of ACP-044 for the Treatment of Acute Postoperative Pain Following Bunionectomy

Inclusion Criteria: * Male or female ≥18 and \<60 years of age at the time of Screening * Has a body mass index (BMI) \<40 kg/m2 * Able to understand and provide signed informed consent * Able to complete subject-reported outcome measures * Is in need of a primary unilateral, first metatarsal bunionectomy with osteotomy and internal fixation under regional anesthesia and sedation * Willing to remain inpatient at the study center for 4 days following surgery Exclusion Criteria: * Has had a contralateral foot bunionectomy in the past 3 months * Has a planned concurrent surgical procedure (e.g. bilateral bunionectomy or collateral procedures like hammertoe correction on the surgical foot) * Any subacute or chronic pain condition or use of a medication that would impair/impact the ability to rate the pain associated with the bunionectomy, in the opinion of the Investigator and Medical Monitor * Has known or suspected regular use of opioids within the previous 6 months * Has taken opioids within 24 hours prior to the scheduled surgery or within five half-lives of the drug, whichever is longer * Has a known or suspected history of drug abuse, a positive drug screen at Screening or Day -1, or a recent (i.e., within the last 5 years) history of alcohol abuse. Subjects using marijuana are not allowed to participate in the study. * Has taken any aspirin (ASA) or non-steroidal anti-inflammatory drugs (NSAIDs) within 2 days prior to the scheduled surgery or within five half-lives of t…