CompletedNot Applicable

Respiratory Muscles After Hospitalisation for COVID-19

Germany50 participantsStarted 2021-06-01

Plain-language summary

Fatigue and exercise intolerance after survived COVID-19-infection might be related to weakness of the respiratory muscles especially following invasive mechanical ventilation in the Intensive Care Unit. The aim of the project is to measure respiratory muscle function and strength in our respiratory physiology laboratory (Respiratory Physiology Laboratory, Department of Pneumology and Intensive Care Medicine, Head: Professor Michael Dreher) in patients who survived a severe COVID-19-infection (25 with a severe course requiring mechanical ventilation in the intensive care unit, 25 with a moderate-severe course requiring administration of supplemental oxygen only, respectively). Based on this data the aim is to develop a model which determines the severity, pathophysiology and clinical consequences of respiratory muscle dysfunction in patients who had been hospitalised for COVID-19. This will potentially prove the importance of a dedicated pulmonologic rehabilitation with respiratory muscle strength training in patients who had been hospitalised for COVID-19.

Who can participate

Age range18 Years

SexALL

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Inclusion Criteria: * 50 patients with survived COVID-19-infection (25 with a severe course requiring mechanical ventilation in the intensive care unit, 25 with a moderate-severe course requiring administration of supplemental oxygen only, respectively) * Patients aged at least 18 years, who are mentally and physically able to consent and participate into the study Exclusion Criteria: * Diagnosis of another disease, which causes a permanent increase in carbon dioxide level in the blood (chronic hypercapnia) or a permanent combined lung weakness (particularly a neuromuscular disease) * Body-mass-index (BMI) \>40 * Expected absence of active participation of the patient in study-related measurements * Alcohol or drug abuse * Metal implant in the body that is not MRI compatible (NON MRI compatible pacemaker, implantable defibrillator, cervical implants, e.g. brain pacemakers etc.) * Slipped disc * Epilepsy * Bound to a wheel chair * Patients who are mentally and physically unable to consent and participate into the study * Patients in an interdependence or with an employment contract with the principal investigator, Co-PI or his deputy. * Emergency hospital stay in the last 4 weeks preceding the day of the measurements

What they're measuring

Twitch transdiaphragmatic pressure in response to supramaximal magnetic stimulation of the phrenic nerve roots

Timeframe: 2 years

Respiratory mouth pressures

Timeframe: 2 years

Trial details

NCT IDNCT04854863

SponsorRWTH Aachen University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2023-07-01