Effect of Ivabradine on Levcromakalim-Induced Symptoms in Individuals With Migraine Without Aura (ILIM)

Inclusion Criteria: * Be able to give voluntary written informed consent to participate. * Have a diagnosis of episodic migraine without aura according to The International Classification of Headache Disorders 3rd Edition. * Be in good general health and without any cardio- or cerebrovascular diseases, psychiatric disorders or other severe comorbidities. * Be 18-60 years of age. * Have a weight between 50-100 kg. * Have a normal standard resting 12-lead ECG at the screening visit with heart rate (HR) ≥ 60 bpm (the inclusion criterium of HR ≥ 60 bpm at screening has previously been used in studies with dosages of ivabradine up to 20 mg as single and multiple doses with no significant adverse events). * Be without any chronic use of medicine. * Have a negative urine-human chorionic gonadotropin (hCG) test at the screening visit if they are female of childbearing potential. Exclusion Criteria: * Suffer from tension type headache, as defined by the The International Classification of Headache Disorders 3rd Edition, more than five days a month on average in the last year. * Are diagnosed with any primary headache disorder apart from migraine without aura as de-fined in The International Classification of Headache Disorders 3rd Edition (relating to tension type headache, see above). * Suffer from any headache 48 hours prior to the start of the experiment or any migraine 72 hours prior to the start of the experiment. * Are allergic to ivabradine or levcromakalim. * Are lactose in…