Evaluation of Typhoid Conjugate Vaccine Effectiveness in Ghana

Inclusion Criteria: In order to be eligible to participate in this study, an individual must meet the following criteria: * Healthy participants aged 9 months to \<16 years (i.e., ≤15 years and 364 days) of age at the time of vaccination * Participants/Parents/legally authorized representative (LAR) who have voluntarily given informed assent (sought from participants aged 12 years to \<16 years) and informed consent * Participants/Parents/LAR living within study target area at the time of vaccination and willing to follow the study procedures and be available for the entire duration of the study Exclusion Criteria: An individual who meets any of the following criteria will be excluded from participation in this study: * Known allergy to any vaccine component * Self-reported ongoing acute and/or chronic illness * Any self-reported coagulopathies * Any medical or social compelling reasons in the judgment of a clinical physician * Self-reported pregnancy/Positive urine pregnancy test or lactating * Previous typhoid vaccination in the last 5 years (proven by the presentation of a vaccine card or self-reporting). Temporary exclusion criteria * Self-reported fever (elevated tympanic (≥38°C) or axillary temperature (≥37.5°C)) within 24 hours of vaccination * Self-reported use of antipyretics within 4hours prior to vaccination * Any other vaccination during the last 4 weeks (proven by the presentation of a vaccine card or self-reporting) * Girls ≥11 years of age with self-report…