RNS System RESPONSE Study

Inclusion Criteria: * Subject has disabling motor simple partial seizures, complex partial seizures, and/or secondarily generalized seizures. Disabling refers to seizures that are severe enough to cause injuries, or significantly impair functional ability in domains including employment, psychosocial education and mobility. * Subject has seizures that are distinct, stereotypical events that can be reliably counted, in the opinion of the investigator, by the subject or parent/caregiver. * Subject had an average of three or more disabling motor simple partial seizures, complex partial seizures and/or secondarily generalized seizures over the two most recent consecutive 30-day periods, with no 30-day period with less than two seizures per subject and/or parent/caregiver report. * Subject failed treatment with a minimum of two anti-seizure medications (used in appropriate doses) with adequate monitoring of compliance and the effects of treatment, as determined by the investigator. * Subject has undergone diagnostic testing as part of his/her standard care that has identified no more than two epileptogenic regions. * Subject is male or a female of childbearing potential using a reliable method of contraception (hormonal, barrier method, surgical or abstention). * Subject is age 12 or older but will be less than age 18 (has not reached 18th birthday) at the time of implantation with the RNS System. * Subject is able to maintain an electronic diary alone or with the assistance of a…