A First in Human, Dose Escalation Study to Evaluate the Safety and Tolerability of BBP-671 in Healthy Volunteers and Patients With Propionic Acidemia or Methylmalonic Acidemia

Inclusion Criteria (Healthy Volunteers): * Subject is male or female 18 to 55 yrs old * Subject has a BMI 18 to 32 kg/m\^2 * Female and male subjects must use effective method of birth control * Female subjects must have negative pregnancy test prior to first dose of study drug * Subject must not have any clinically significant history or presence of ECG findings * Subject must be in good general health Inclusion Criteria (PA or MMA Patients): * Patient is male or female 15 to 55 yrs old * Patient has a BMI 18 to 32 kg/m\^2 * Female and male patients must use effective method of birth control * Female patients must have negative pregnancy test prior to first dose of study drug * Patient must have confirmed PA or MMA diagnosis * Patient with MMA must have elevated plasma MMA levels * Patient is willing to provide access to medical records for the last 6-12 months of care prior to study initiation * Patient is on consistent disease management and treatment regimen is stable for at least 30 days prior to study initiation. Exclusion Criteria (Healthy Volunteers): * Subject has used prescription drugs (contraceptive medications are allowed) within 4 weeks before first dose of study drug or over-the-counter medication within 7 days of the first dose of study drug * Subject who is unable or unwilling to refrain from wearing contact lenses during participation in the study. * Subject has a history of dry eye or eye surgery, including radial keratotomy and LASIK surgery. * Subjec…