Stopped: Study was terminated as data became available from Phase 3 trials of perioperative regimens combining chemotherapy with immunotherapy showing improved efficacy outcomes versus chemotherapy alone.
This study will evaluate the surgical safety and feasibility of atezolizumab plus tiragolumab alone or in combination with platinum-based chemotherapy as neoadjuvant treatment for participants with previously untreated locally advanced non-small cell lung cancer (NSCLC). The study will also evaluate the efficacy, pharmacokinetics, immunogenicity, and safety of atezolizumab plus tiragolumab alone or in combination with platinum-based chemotherapy as neoadjuvant treatment, followed by adjuvant atezolizumab plus tiragolumab or adjuvant platinum-based chemotherapy.
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Number of Participants With Surgical Delays
Timeframe: Up to approximately 4.7 months
Number of Participants With Operative and Post-operative Complications
Timeframe: From day of surgery up to end of safety follow-up (up to approximately 17.5 months)
Number of Participants With Surgical Cancellations Related to Study Treatment
Timeframe: Up to approximately 4.7 months
Number of Participants With Adverse Events (AEs)
Timeframe: From signing of informed consent to up to 90 days after the final dose of study treatment (Up to approximately 1.7 years)
Major Pathological Response (MPR) Rate
Timeframe: At the time of surgical resection (From Day 114 to Day 144)