Stopped: Study was terminated as data became available from Phase 3 trials of perioperative regimens combining chemotherapy with immunotherapy showing improved efficacy outcomes versus chemotherapy alone.
This study will evaluate the surgical safety and feasibility of atezolizumab plus tiragolumab alone or in combination with platinum-based chemotherapy as neoadjuvant treatment for participants with previously untreated locally advanced non-small cell lung cancer (NSCLC). The study will also evaluate the efficacy, pharmacokinetics, immunogenicity, and safety of atezolizumab plus tiragolumab alone or in combination with platinum-based chemotherapy as neoadjuvant treatment, followed by adjuvant atezolizumab plus tiragolumab or adjuvant platinum-based chemotherapy.
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Number of Participants With Surgical Delays
Timeframe: Up to approximately 4.7 months
Number of Participants With Operative and Post-operative Complications
Timeframe: From day of surgery up to end of safety follow-up (up to approximately 17.5 months)
Number of Participants With Surgical Cancellations Related to Study Treatment
Timeframe: Up to approximately 4.7 months
Number of Participants With Adverse Events (AEs)
Timeframe: From signing of informed consent to up to 90 days after the final dose of study treatment (Up to approximately 1.7 years)
Major Pathological Response (MPR) Rate
Timeframe: At the time of surgical resection (From Day 114 to Day 144)