NAVA vs. CMV Crossover in Severe BPD (NCT04821453) | Clinical Trial Compass
TerminatedNot Applicable
NAVA vs. CMV Crossover in Severe BPD
Stopped: DSME recommendation due to recommendations on study redesign.
United States12 participantsStarted 2021-09-13
Plain-language summary
This prospective, unblinded, pilot randomized cross-over trial of 2 modes of mechanical ventilation will compare measures of pulmonary mechanics, respiratory gas exchange, and patient comfort between conventional flow triggered mechanical ventilation and neurally adjusted ventilatory assist (NAVA) among 20 prematurely born infants and young children receiving invasive respiratory support for severe bronchopulmonary dysplasia (BPD).
Who can participate
Age range24 Months
SexALL
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Inclusion criteria
✓. Gestational ages (GA) ≤ 32 weeks
✓. Current age between 36 weeks postmenstrual age (PMA) and 2 years corrected age
✓. Severe BPD \[as per National Institutes of Health (NIH) consensus definition\] diagnosed at 36 weeks postmenstrual age
✓. Receiving invasive mechanical ventilation for ongoing lung disease
✓. Not expected to be ready for extubation within 11 days following enrollment
✓. Parental consent
Exclusion criteria
✕. Severe congenital anomalies
✕. Known diaphragmatic defect
✕. Current treatment with high frequency mechanical ventilation
✕. Do not resuscitate (DNR) Status or Futility of Care