Impact of Contraceptives on Cervico-Vaginal Mucosa

Inclusion Criteria: * Age 18 to 50 years, inclusive * In general good health without any significant systemic disease and with an intact uterus and cervix. * History of Pap smears and follow-up consistent with standard, local clinical practice or willing to undergo a Pap smear at Visit 1 * Willing to give voluntary consent and sign an informed consent form * Willing and able to comply with protocol requirements, including accepting randomization to study contraceptive products * If currently on a contraceptive product, willing to go off products and use condoms for birth control for a specified time * If in a relationship, must be with a partner who is not known to be HIV positive and has no know risk of sexually transmitted infections (STIs) Exclusion Criteria: * Positive pregnancy test or plans to become pregnant during the course of the study * Currently exclusively breastfeeding or planning to exclusively breastfeed during the course of the study * Less than six weeks from a delivery of an infant greater than 20 weeks gestation * Use of DMPA in the past 4 months * Clinical signs and symptoms of menopause * Current WHO or CDC medical eligibility criteria level 3 or 4 for any contraceptive product to which a participant could receive at the clinical site * History of sensitivity/allergy to any component of the study product, topical anesthetic, or to both silver nitrate and Monsel's solution * Current infection with Trichomonas vaginalis (TV), Neisseria gonorrhea (NG), C…