Previous cross-sectional studies have shown that informing cancer patients about potential chemotherapy-related cognitive symptoms may negatively affect perceived cognitive symptoms and verbal memory performance. A multicenter, randomized study in newly diagnosed breast cancer patients receiving (neo) adjuvant chemotherapy was performed to evaluate this Adverse Information Effect (AIE) over time and investigated whether inviting patients to self-affirm can reduce such AIEs on perceived cognitive symptoms and cognitive test performance.
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Between-group differences in mean change in the perceived frequency of cognitive symptoms from baseline to T1, and from baseline to T2.
Timeframe: Prior to chemotherapy-initiation (baseline; T0), six months (T1), and twelve months (T2) later
Between-group differences in mean change in the perceived severity of cognitive symptoms from baseline to T1, and from baseline to T2.
Timeframe: Prior to chemotherapy-initiation (baseline; T0), six months (T1), and twelve months (T2) later
Between-group differences in mean change in verbal memory performance from baseline to T1, and from baseline to T2.
Timeframe: Prior to chemotherapy-initiation (baseline; T0), six months (T1), and twelve months (T2) later
Between-group differences in mean change in information processing speed and executive functioning from baseline to T1, and from baseline to T2.
Timeframe: Prior to chemotherapy-initiation (baseline; T0), six months (T1), and twelve months (T2) later