Active — Not RecruitingNot Applicable

The Effect of Helminth Infection Plus COVID-19 Infection on the Immune Response and Intestinal Microorganisms

India1,500 participantsStarted 2021-06-01

Plain-language summary

This is a pilot, cross-sectional, sample collection study to characterize the immune response and intestinal microorganisms in people with and without COVID-19 antibodies and helminth infection.

Who can participate

Age range

5 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Able to provide informed consent. Exclusion Criteria: * Poor venous access precluding venipuncture. * History of any illness or condition which, in the investigator's judgment, may substantially increase the risk associated with the participant's participation in the protocol, or compromise the scientific objectives. Participants may be co-enrolled in other studies; however study staff should be notified of co-enrollment.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Number of participants with helminth infections

Timeframe: Day 1

Number of participants with SARS-CoV-2 antibodies

Timeframe: Day 1

Number of participants with positive malaria test

Timeframe: Day 1

Average Differential blood count

Timeframe: Day 1

Average Hematocrit levels

Timeframe: Day 1

Number of participants with latent tuberculosis infection

Timeframe: Day 1

Number of participants with Wuchereria bancrofti infection

Timeframe: Day 1

Number of participants with Strongyloides stercoralis infection

Trial details

NCT IDNCT04813328

SponsorNational Institute of Allergy and Infectious Diseases (NIAID)

Sponsor typeNIH

Study typeOBSERVATIONAL

Primary completion2026-04

View on ClinicalTrials.gov More COVID-19 trials

Who can participate

Age range

5 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Number of participants with helminth infections

Timeframe: Day 1

Number of participants with SARS-CoV-2 antibodies

Timeframe: Day 1

Number of participants with positive malaria test

Timeframe: Day 1

Average Differential blood count

Timeframe: Day 1

Average Hematocrit levels

Timeframe: Day 1

Number of participants with latent tuberculosis infection

Timeframe: Day 1

Number of participants with Wuchereria bancrofti infection

Timeframe: Day 1

Number of participants with Strongyloides stercoralis infection