CompletedNot Applicable

Vitamin D Receptor, Interleukin-1A and Interleukin-1B Gene Polymorphisms in Periodontitis

Turkey (Türkiye)200 participantsStarted 2018-01-29

Plain-language summary

Background: The aim of the study is to find out the prevelance of VDR (rs731236), IL1B (rs1143634) and IL1A (rs1800587)gene polymorphisms in Turkish population and their association with stage III grade B / C periodontitis. Methods: Individuals who were found to be systemically and periodontally healthy (N = 100) after clinical and radiographic examination and who were diagnosed with Stage III Grade B / C periodontitis (N = 100) were included in the study. Gingival index, Plaque index, bleeding on probing, clinical attachment level and pocket depths of the patients were recorded. subjects genotyped for rs731236, rs1143634 and rs1800587 gene polymorphisms with Real Time Polymerase Chain Reaction.

Who can participate

SexALL

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Inclusion Criteria: systemically healthy, previously untreated periodontitis patients Exclusion Criteria: presence of systemic disease such as diabetes, rheumatic fever, liver or kidney diseases, neurologic deficiencies, immunologic diseases; pregnancy; smoking; receive of any medication which may affect periodontal tissues; used antibiotics for any purpose within 6 months.

What they're measuring

IL-1A gene polymorphism

Timeframe: baseline

Interleukin-1B gene polymorphism

Timeframe: baseline

Vitamin D Receptor gene polymorphism

Timeframe: baseline

Trial details

NCT IDNCT04806971

SponsorMarmara University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2019-09-27

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