The Influence of Nonspecific Immunostimulation on Changes in the Concentration of iNKT Cells

Inclusion Criteria: * Children of both genders aged 5 to 17 years. * Children with grass pollen-induced allergic rhinitis recognized and treated according to current ARIA (Allergic Rhinitis and its Impact on Asthma) recommendations. * Positive skin prick test to grass pollen allergens or positive specific IgE (defined as ≥ class 2, ≥ 0,70 kU/l) against timothy grass pollen allergens. * Presentation of clinical symptoms of the allergic rhinitis (rhinorrhea, nasal congestion, nasal itching, sneezing) in at least two recent grass pollen seasons in Poland before inclusion in the study. * Proper use of polyvalent mechanical bacterial lysate sublingual tablets. * Not using drugs to alleviate the symptoms of allergic rhinitis in the last 7 days prior to enrollment in the study: intranasal glucocorticosteroids, intranasal, oral and ophthalmic antihistamines, intranasal and oral alpha-mimetics, intranasal anticholinergics, antileukotrienes and cromones. * Written informed consent obtained from parents/guardians before any study related procedures are performed. Exclusion Criteria: * Patient received mechanical bacterial lysate immunostimulation within the previous 12 months before randomisation visit. * Patient received chemical bacterial lysate immunostimulation within the previous 6 months before randomisation visit. * Patient received oral/subcutaneous allergen-immunotherapy within the previous 3 years before the start of the study. * Other chronic conditions of the nose or nasa…