Comparing the Addition of an Anti-Cancer Drug, Pomalidomide, to the Usual Chemotherapy Treatment (Daunorubicin and Cytarabine Liposome) in Newly Diagnosed Acute Myeloid Leukemia With Myelodysplastic Syndrome-Related Changes

Inclusion Criteria: * Pathological confirmation of AML as defined by histologic, morphologic, or cytological evidence/confirmation of \>= 20% blasts in bone marrow aspirate and/or biopsy * Must meet criteria for t-AML or AML with MRC as defined by the 5th Edition of the World Health Organization (WHO) Classification of Myeloid Neoplasms or the International Consensus Classification (ICC) of Myeloid Neoplasms. Patients must meet one of the following criteria: * Therapy-related AML (AML derived from prior chemotherapy or radiation therapy) * AML originating from prior hematologic malignancy (MDS, CMML, or MPN) * AML with myelodysplasia-related cytogenetic abnormalities: * One of the following cytogenetic abnormalities: * Complex karyotype (3 or more unrelated chromosomal abnormalities in the absence of other class-defining recurrent genetic abnormalities as defined by WHO or ICC) * -7/del(7q) * Del(5q)/t(5q)/add(5q) * +8 * i(17q) * -17/add(17p) or del(17p) * Del(20q) * -13/del(13q) * Del(11q) * Del(12p)/t(12p)/add(12p) * idicX(q13) * AML with myelodysplasia-related mutations: Must have a mutation in one of the following genes: * ASXL1 * BCOR * EZH2 * RUNX1 * SF3B1 * SRSF2 * STAG2 * U2AF1 * ZRSR2 * No prior treatment for AML other than cytoreductive doses of hydroxyurea or leukapheresis * Age \>= 18 and =\< 75 years on day of signing informed consent are eligibl…