Study on the Peristaltic Direction of GI Anastomosis in Roux-en-Y Reconstruction

Inclusion Criteria: * 1\) Pathological examination confirmation the adenocarcinoma of stomach before surgery * 2\) Physical conditions compliance with the requirements for curative gastrectomy * 3\) Consent to undergo the D2 lymphadenectomy, and the dissected proportion of stomach no less than 2/3 * 4\) Comply with the protocol during the whole study period * 5\) No neoadjuvant therapy administration * 6\) Sign informed consent and permission of withdraw in the whole study period * 7\) Consent to provide the tissue specimens after surgery for this study * 8\) Estimation the overall survival after surgery no less than 6 months * 9\) No anesthesia or operation contraindication disease * 10\) cT1-4N0-2M0 stage demonstration by CT and endoscopic ultrasonography examinations * 11\) Negative cytological detection in operation * 12\) No seriously concomitance's diseases * 13\) Karnofsky Performance Scores (KPS) more than 60 * 14\) Examined lymph node count no less than 16 Exclusion Criteria: * 1\) Women during pregnant stage and breast-feed stage * 2\) Women of childbearing age without any contraceptive measures * 3\) Severe congestive heart failure, frequent arrhythmia, or myocardial infarction within 12 months * 4\) Immunosuppressive therapists for organ transplantation * 5\) Seriously uncontrolled recurrent infection * 6\) other malignant tumors * 7\) No abilities of self-knowledge or mental disorders * 8\) Participating in other clinical trials * 9\) Siewert I and II esophago…