Safety and Performance Study of Large Hole Vascular Closure Device - FRONTIER V Study

Inclusion Criteria: * Over 18 years of age. * Subject is willing and able to provide appropriate study-specific informed consent, follow protocol procedures, and comply with follow-up visit requirements. * Clinically indicated for an endovascular procedure using a common femoral arteriotomy created by a 14 - 22 F sheath. General Exclusion Criteria: * Severe acute non-cardiac systemic disease or terminal illness with a life expectancy of less than four months. * Evidence of systemic bacterial or cutaneous infection, including groin infection. * Known bleeding diathesis (including sever liver disease), definite or potential coagulopathy, platelet count \< 100,000/µl or patients on long term anticoagulants with an INR greater than 2 at time of procedure or known type II heparin-induced thrombocytopenia. * Previous groin surgery within the region of the ipsilateral access. * Severe; claudication or peripheral vascular disease (e.g. Rutherford category 3 or greater or ABI \< 0.5), documented untreated iliac artery diameter stenosis \> 50% or previous bypass surgery/stent placement in the common femoral artery of ipsilateral limb. * Known allergy to any of the materials used in the PerQseal® + or PerQseal® Introducer (refer to Investigator's Brochure for materials list). * Subject has undergone a percutaneous procedure using a non-absorbable vascular closure device (excluding suture mediated) for haemostasis in the ipsilateral target leg. * Patients that have undergone a percuta…