Adolescence is a time of heightened reward sensitivity and greater impulsivity. On top of this, many teenagers experience chronic sleep deprivation and misalignment of their circadian rhythms due to biological shifts in their sleep/wake patterns paired with early school start times. Many studies find that this increases the risk for substance use (SU). However, what impact circadian rhythm and sleep disruption either together or independently have on the neuronal circuitry that controls reward and cognition, or if there are interventions that might help to modify these disruptions is unknown. Project 2 (P2) of the CARRS center will test an innovative and mechanistic model of brain circuitry that uses multi-method approaches, takes a developmental perspective, and incorporates key sleep and reward constructs.
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Weekday Sleep Duration--Actigraphy & Diaries
Timeframe: Baseline (2 Weeks), T2 (2 weeks)
Circadian Timing-Dim Light Melatonin Onset
Timeframe: Baseline Overnight Visit (T1) & T2 Overnight Visit(2 weeks later). Always on a Friday.
Circadian Alignment
Timeframe: Baseline overnight (T1), T2 overnight (2 weeks after T1)
Reward motivation (Behavioral)
Timeframe: Baseline overnight (T1) vs. T2 overnight (2 weeks after T1)
Behavioral Inhibition
Timeframe: Baseline overnight (T1) vs. T2 overnight (2 weeks after T1). Always on a Friday.
Neural correlates of Impulse control
Timeframe: Baseline overnight (T1) vs. T2 overnight (2 weeks after T1). Always on a Friday.
Neural correlates of Reward Anticipation
Timeframe: Baseline overnight (T1) vs. T2 overnight (2 weeks after T1). Always on a Friday.
Neural Correlates of Reward Receipt
Timeframe: Overnight visits at end of T1 & T2 (two weeks after T1)