Anorexia iN Cancer Patients: ANCHOR (NCT04791254) | Clinical Trial Compass
UnknownNot Applicable
Anorexia iN Cancer Patients: ANCHOR
United Kingdom450 participantsStarted 2021-07-15
Plain-language summary
The rationale for this study is to prospectively investigate the outcomes of patients undergoing standard dietetic interventions alongside treatment for their advanced gastrointestinal cancers, and to further characterise the relationship with body composition.
A number of patients will be enrolled in a sub-study investigating the neuronal-enteroendocrine-hypothalamic axis.
Gut hormone study. Our hypothesis is that proinflammatory cytokines produced by the tumour can not only affect appetite directly through the vagal and the central melanocortin system but also indirectly though the enhanced EEC activity; either through increased number or increased function.
In this study, the investigators will explore and compare the pattern and levels (pre-prandial and post prandial) of the pro-inflammatory cytokines and gut hormones between stage-standardised anorexic and non-anorexic cancer patients and age-matched healthy controls.
Who can participate
Age range18 Years
SexALL
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Inclusion criteria
✓. Patients with stage IV gastric or GOJ adenocarcinoma or locally advanced non-resectable adenocarcinoma
. Patients not undergoing systemic anti-cancer treatment at The Christie hospital, for example patients not deemed fit enough for treatment, patients having alternative treatments such as radiotherapy or surgery, or patients referred for 2nd opinions.
✕. Recent myocardial infarction or stroke
✕. Recent abdominal, eye or thoracic surgery
✕. A recent respiratory tract infection (within 3 weeks)
✕. Any chest pain on the day of the test
✕. A positive COVID-19 test
✕. Symptoms of dysphagia of any cause, oesophageal or gastric obstruction (assessed via medical history/O'Rourke score). Patients with O'Rourke score ≥2 will be excluded.