By InvitationNot Applicable

Auditory Stimulation Effects on Sleep and Memory in Patients With Epilepsy

United States24 participantsStarted 2021-01-21

Plain-language summary

This study will investigate the role of coordinated brain rhythms during sleep in memory consolidation and determine whether playing precisely timed brief bursts of noise can enhance these rhythms and improve memory in epilepsy inpatients with implanted hippocampal electrodes.

Who can participate

Age range12 Years – 65 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Inpatients with epilepsy * Aged 12-65 * Undergoing clinically indicated continuous scalp and intracranial EEG monitoring with implanted hippocampal electrodes * Fluent in English * Able to give informed consent/assent (for minors aged 12-17 or adults with an appointed guardian) Exclusion Criteria: * Intellectual disability impairing ability to perform task * Motor problems that preclude finger tapping task * Previous surgery anticipated to disrupt coordination of sleep oscillations in the circuitry of interest

What they're measuring

Changes in slow oscillation-spindle-hippocampal ripple coupling

Timeframe: Three nights of sleep within three weeks

Trial details

NCT IDNCT04788628

SponsorMassachusetts General Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-03-31

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