UnknownEarly Phase 1

Multi-Nutrient Supplement for Radio-Protection

30 participantsStarted 2024-07-01

Plain-language summary

Exposure to radiation, such as during routine CTs, bone scans, or X-rays, causes oxidative stress which can damage the DNA (your genetic material) within your white blood cells. While the amount of DNA damage that may occur from one scan is not harmful to your overall health, there could be concerning damage in patients who are constantly exposed to this radiation. Currently, there is no way to prevent DNA damage during a medical scan. One potential way to fight the oxidative stress caused by radiation is to take an antioxidant before a scan. The purpose of this study is to see if a combination of antioxidants can protect someone from the damage that radiation causes to the DNA of their white blood cells.

Who can participate

Age range18 Years – 74 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age 18 to 76 years. * Scheduled for bone scan procedure at the Juravinski Hospital. Exclusion Criteria: * History of smoking within six months prior to study enrollment. * Known hypersensitivity reactions to any of the ingredients in the MNSRP. * Chemotherapy or radiation therapy within six months prior or one month following study enrollment. * Individuals currently taking vitamin or mineral supplements that contain antioxidants will be considered on a case-by-case basis but will be asked to refrain from intake for at least two weeks prior to partaking in this study.

What they're measuring

Number of gamma-H2Ax foci per PBMC nucleus

Timeframe: Three hours following radiation exposure

Trial details

NCT IDNCT04781868

SponsorMcMaster University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-07-01

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