Noise-Induced Hearing Loss-Acute Exposure Treatment

Inclusion Criteria: * Patients who are scheduled to undergo a skull-based surgery that requires at least 45 minutes of surgical-drilling * At least 18 years of age * Air conduction thresholds in the non-operated ears are to be no worse than 25 decibel (dB) hearing loss (HL) for pure tone average 0.5, 1, and 2 kilohertz (kHz) with no individual threshold greater than 30 dB HL, and no worse than 45dB HL at 4 kHz at screening. * Observed air-bone gap \< 10 dB HL at 0.5, 1, 2, and 4 kHz, with normal tympanometry. * Ability to understand and willingness to sign an Institutional Review Board (IRB) approved written informed consent document. Exclusion Criteria: * History of known sulfa allergy or hypersensitivity to carbonic anhydrase inhibitors * History of moderate-to-severe kidney or liver disease * Acute viral, bacterial, fungal or parasitic infection * History of seizures * Currently pregnant or breast-feeding * Any current or history of ear disorder and/or central auditory dysfunction in the non-operated ear * History of ototoxic drug use * Current use of strong/moderate 3A4 inhibitor/inducer and grapefruit juice