Arginine Supplementation to Improve Cardiovascular and Endothelial Function After NSAID Treatment

Inclusion Criteria: * No abnormal findings on medical history, screening physical examination, hematology, biochemistry, urinalysis (including specific gravity), and vital signs (sitting blood pressure, sitting pulse rate, sitting respiratory rate and body temperature) within 2 weeks of commencement of the study. * Normal fasting lipid profile * Non-smoking * Clear venous access in upper limbs * BMI: 18-30 * No history or signs of drug abuse * No other medication 4 weeks before or during the study * Informed written consent Exclusion Criteria: * Any history of allergy to NSAIDS or arginine * Significant medical conditions * Pulse rate \<50 bpm * Sitting systolic blood pressure \<80 or \>160 mmHg * Sitting diastolic pressure \<60 or \>100 mmHg * Baseline endothelial dysfunction (as defined by EndoPAT; LnRHI \<0.51) * Participation in other clinical study 8 weeks before or during the study * Donation of blood 8 weeks before or during the study * Those on medication that cannot be discontinued