UnknownPhase 1/2

Efficacy and Safety of Colistin Based Antibiotic Therapy

Egypt60 participantsStarted 2017-09-01

Plain-language summary

To evaluate the efficacy and safety of antibiotic combinations containing Colistin in the treatment of children with multidrug-resistant gram negative infections admitted in the pediatric surgery intensive care unit. The main outcome measure is clinical and microbiological responses to therapy. The secondary outcome is the occurrence of adverse events during Colistin combination treatment.

Who can participate

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * All children with culture proven nosocomial infections due to multidrug resistance gram-negative organisms Exclusion Criteria: * 1\. Patients who started on Colistin treatment outside the pediatric surgery intensive care unit and transferred to the unit afterward will be excluded. 2\. Patients who will receive \<6 doses of intravenous Colistin will be excluded. 3\. Patients received Imipenem or Colistin-Imipenem compination as empirical antibiotic.

What they're measuring

Hemodynamic Parameters Measurement ,heart beating rate.

Timeframe: 2 year

Hemodynamic Parameters Measurement ,body temperature

Timeframe: 2 year

Hemodynamic Parameters Measurement ,respiratory rate.

Timeframe: 2 year

Hemodynamic Parameters Measurement ,blood pressure

Timeframe: 2 year

Hemodynamic Parameters Measurement ,partial oxygen saturation pressure

Timeframe: 2 year

Hemodynamic Parameters Measurement and Septic Markers, serum lactate

Timeframe: 2 year

Hemodynamic Parameters Measurement ,serum creatinine

Timeframe: 2 year

Trial details

NCT IDNCT04764058

SponsorAin Shams University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2019-09-01

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