Study to Evaluate Safety and Activity of TRL1068 in Prosthetic Joint Infections

Inclusion Criteria: * Diagnosis of PJI of the knee or hip * Identified pathogen(s) must be susceptible to antibiotic regimen * Planned/scheduled for primary two-stage exchange arthroplasty * BMI \< 40 kg/m² * Willing and able to provide written informed consent * Willing to perform and comply with all study procedures including attending clinic visits as scheduled. * Men and women of child bearing potential (WOCBP) must be willing to practice a highly effective method of contraception Exclusion Criteria: * Evidence of active infection other than bacterial PJI of the knee or hip * Inability to receive or intolerant to pathogen-appropriate systemic or oral antibiotic therapy * Chronic obstructive pulmonary disease (COPD) * Child-Pugh score \> 6 * Congestive heart failure * Immunocompromised individuals, including those receiving immunosuppressive doses of corticosteroids * Active malignancy, or history of malignancy or chemotherapy within the past 2 years * Active or history of autoimmune disease * Uncontrolled diabetes, defined as hemoglobin A1c \> 7.4% * Clinically significant abnormality on electrocardiogram (ECG) that would preclude subject from undergoing two-stage exchange arthroplasty * Clinically significant serum chemistry or hematology abnormalities * Any acute illness within 14 days of Day 1 that could confound the evaluation of safety evaluation * Known or suspected intolerance or hypersensitivity to any biologic medication * Received a therapeutic antibody or bi…