MGTA-145 + Plerixafor in the Mobilization of HSCs for Allogeneic Transplant in Hematologic Malignancies

Inclusion Criteria: Donor Inclusion Criteria: * Donor medical suitability and eligibility will be determined following Institution or NMDP/Be The Match standards * Age 18-65 years old at the time of signing informed consent * 8/8 (HLA- A, B, C, and DRB1) HLA-matched sibling or volunteer unrelated donor * Fulfill Institution or NMDP/Be The Match criteria to serve as a mobilized blood cell donor * Serum creatinine \< 1.5 x institution upper limit of normal (ULN) or estimated creatinine clearance (CRCL) \> 50 mL/min using the Modification of Diet in Renal Disease Study (MDRD) equation or similar method Recipient Inclusion Criteria: * At least 18 years old at the time of signing informed consent * Has an available 8/8 (HLA- A, B, C, and DRB1) HLA-matched sibling or volunteer unrelated donor willing to donate peripheral blood stem cells (PBSC) for transplant * Fulfill additional individual Transplant Center Criteria for transplant beyond NMDP/Be The Match criteria * One of the following diagnoses: * Acute myelogenous leukemia (AML) in 1st remission or beyond with ≤ 5% marrow blasts and no circulating blasts. Documentation of bone marrow assessment will be accepted within 45 days prior to the date of consent. * Acute lymphoblastic leukemia (ALL) in 1st remission or beyond with ≤ 5% marrow blasts and no circulating blasts. Documentation of bone marrow assessment will be accepted within 45 days prior to the date of consent. * Patients with myelodysplasia (MDS) with no circ…