10 participants aged 3 years and over with tyrosinaemia or alkaptonuria will be prescribed Tyr sphere following an assessment of their individual needs by their dietitian. All participants will enter a 4-week evaluation period, assessing adherence and gastrointestinal tolerance. Evaluations of Tyr sphere's palatability are made at the end of the evaluation period. Dried blood spots are taken on days 1 and 28 and once per week in between. Participants who continue to take the product at the end of their evaluation period will enter a follow-up period during which metabolic control, anthropometric and nutritional status data will be collected during the yearly standard of care routine visits.
Age range
3 Years
Sex
ALL
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Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Change in adherence to recommended amounts of Tyr sphere
Timeframe: Recorded daily on days 1-28
Change in gastrointestinal tolerance
Timeframe: Recorded daily on days 1-28
Patient evaluation of Tyr sphere's palatability
Timeframe: Day 28, end of acceptability phase
Change in metabolic control: tyrosine levels
Timeframe: Day 1, week 1, week 2, week 3, week 4, day 28
Change in metabolic control: phenylalanine levels
Timeframe: Day 1, week 1, week 2, week 3, week 4, day 28