Ticagrelor De-escalation Strategy in AMI Patients

Inclusion Criteria: * Diagnosis with acute myocardial infarction. * Age ≥19 year-old * Successful PCI with ultrathin bioresorbable polymer sirolimus-eluting stents (Orsiro; Biotronik AG). * Provision of informed consent. Exclusion Criteria: * Any prior event of hemorrhagic stroke or ICH. * Active bleeding (e.g., GI bleeding, ICH) or high-risk of serious bleeding. * Bleeding diathesis or coagulopathy (e.g., hemoglobin ≤ 10 g/dL or platelet count \< 100,000/μL, bleeding needing transfusion within 30 days, and so on). * Allergy to stent metal, contrat media, and antiplatelet regimens. * Moderate to severe hepatic dysfunction (Child-Pugh class B or C). * Need for oral anticoagulation therapy. * Current or potential pregnancy. * Currently treated with strong CYP3A4 inhibitors. * Life expectancy \<1 year.