Dexmedetomidine Versus Propofol for Sedation During Awake Endotracheal Intubation (NCT04753515) | Clinical Trial Compass
CompletedPhase 4
Dexmedetomidine Versus Propofol for Sedation During Awake Endotracheal Intubation
China100 participantsStarted 2021-03-05
Plain-language summary
The purpose of this study is to compare the sedation effect of dexmedetomidine and propofol when they are both combined with midazolam and remifentanil during awake endotracheal intubation.
Who can participate
Age range18 Years – 65 Years
SexALL
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Inclusion criteria
✓. Age 18-65 Years old;
✓. scheduled for elective surgery under general anesthesia with oral tracheal intubation;
✓. The American Society of Anesthesiologists(ASA) grade is I or II, and the cardiac function is 1-2;
✓. Body mass index (BMI) 18-30 kg/m2.
Exclusion criteria
✕. Patients have severe cardiac diseases (cardiac function grading greater than grade 3/arrhythmia including sick sinus syndrome, atrial fibrillation, atrial flutter, atrioventricular block, frequent ventricular premature, multiple ventricular premature, ventricular premature R on T, ventricular fibrillation and ventricular flutter/acute coronary syndrome) or respiratory failure or hepatic failure or renal failure;
✕. body mass index (BMI) ≥30 kg/m2 or \<18 kg/m2;
✕. Patients with poor blood pressure control (receive regular antihypertensive medical treatment but still have systolic blood pressure \> 150 mmHg and/or diastolic blood pressure \> 90 mmHg);
✕. Patients with a higher risk of reflux and aspiration, such as full stomach, gastrointestinal obstruction, gastroparesis, and pregnant women;