Comparison of Hypothermic Versus Normothermic Ex-vivo Preservation.

GRAFT: Inclusion criteria: DCD: * no absolute contraindications as per Italian National Transplant center (CNT) * donor age ≤70 years * witnessed and documented cardiac arrest * macro-vescicular steatosis \<30% at liver biopsy * necrosis \<5% at liver biopsy * fibrosis \<2 as per Ishak's score at liver biopsy * arteriolar thickening \<60% at liver biopsy * WIT ≤160 minutes * ALT \<1000 UI/L during NRP * downward trend lactate during NRP DBD: * no absolute contraindications as per Italian National Transplant center (CNT) * donor age \> 70 years * macro-steatosis between 30 and 50% at liver biopsy Exclusion criteria: DCD: * absolute contraindications as per Italian National Transplant center (CNT) * donor age \>70 years * macro-vescicular steatosis \>30% at liver biopsy * necrosis \>5% at liver biopsy * fibrosis \>2 as per Ishak's score at liver biopsy * severe macroangiopathy (arteriolar thickening \>60% at liver biopsy) * WIT \>160 minutes * ALT \>1000 UI/L during NRP * uptrend lactate during NRP DBD: * absolute contraindications as per Italian National Transplant center (CNT) * donor age \< 70 years * macro-steatosis between \> 50% at liver biopsy RECIPIENTS Inclusion criteria: * Subject must be greater than or equal to 18 years of age. * Subject with end-stage liver disease who is actively listed for primary liver transplantation * Subject, or a legally authorized representative, has given informed consent to participate in the study Exclusion criteria: * Sub…