Assessing Metabolic and Sleep Consequences of Overnight Home Parenteral Nutrition

Inclusion Criteria: * Adult male or non-pregnant female volunteers (age 18-79) * Short bowel syndrome diagnosis * Able and willing to give consent and comply with study procedures * Currently on routine home parenteral nutrition (at least 6 months) Exclusion Criteria: * Blind, deaf or unable to speak English * Women who are pregnant or nursing * Diabetes diagnosis or currently taking or intending to take any diabetes medication or medications influencing sugars including oral glucocorticoids, growth hormone, erythropoietin, or chemotherapeutic * Current use of sleep medication and melatonin * With skin condition that precludes wearing sensors * Within the last year, bariatric surgery or pregnancy * Within the last one month, acute infections or illnesses requiring medical attention, hospitalizations, Emergency Department visits, blood transfusions, blood loss, blood donations * Major changes in diet or physical activity level in the past 3 months * Sleep and circadian disorders (such as obstructive sleep apnea and delayed sleep phase syndrome) * Anticipated barriers or challenges to daytime and/or overnight cycled infusions