Study Evaluating MyoRegulator® Treatment in Post-Stroke Upper Limb Spasticity

Inclusion Criteria: * ≥ 18 to \< 85 years of age * First single focal unilateral hemisphere lesion with diagnosis verified by brain imaging (MRI or CT scans) that occurred at least 6 months prior to study enrollment * At least 6 weeks of stable UE spasticity symptoms (as confirmed by medical history) with a baseline Modified Ashworth Scale (MAS) score of 1+ to 3 (on the 0, 1, 1+, 2, 3, 4 scale), inclusive, in the wrist flexor muscles * Willing to forgo botulinum toxin, phenol or alcohol injections into the muscles of the limb targeted for the study treatment; intrathecal baclofen; digitalis, and morphine for the subject's duration in the study * Willing to forgo upper extremity physical and occupational therapy for the duration of the study (lower extremity PT and OT are allowed) * Willing to maintain current regiment for oral spasticity medication(s) and neurotransmitter medication(s) for the subject's duration in the study * Cognitive function sufficient to understand the experiments and follow instructions (per interview with appropriate clinician) Exclusion Criteria: * Fixed contractures or profound muscle atrophy of the target spastic wrist to be treated * Change in antispastic oral medication (baclofen, clonidine, benzodiazepine, dantrolene, gabapentin, tizanidine) in the 2 months prior to study enrollment * Use of digitalis, morphine, or intrathecal pump in the week prior to study enrollment * Prior botulinum toxin injection(s) into the muscles of the limb targeted …