SonoClear Acoustic Coupling Fluid (ACF) Mimicking Brain Tissue

Inclusion Criteria: * A diffuse malignant glial tumour (high (grade III and IV) or low grade (grade I-II) is suspected from the diagnostic MRI scan * A tumour that extends at least 3 cm in depth from the surface of the brain (confirmed by MRI) * Pre- or peri-procedural confirmed histopathology of glioma * ≥18 years of age * Karnofsky performance status ≥ 70 * Life expectancy of more than 30 days at the time of the procedure * Negative pregnancy test for female subjects of childbearing potential Exclusion Criteria: * Not able to give consent (e.g. severe cognitive impairment) * History of brain radiation therapy * Recent meningitis (within 6 months prior to screening visit) * Other active infection (within 30 days prior to screening visit) * Immuno-incompetent patient (e.g. failing immune system due to AIDS) * Patients taking immune-suppressive medication * Intended biopsy only (meaning: cases not suitable for resection) * Known hypersensitivity to egg protein * Known hypersensitivity to soybean or peanut protein * Known Hypersensitivity to glycerol * Known Hypersensitivity to polysorbates * Pregnant or lactating females or females who intend to become pregnant during the time of the study